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. Author manuscript; available in PMC: 2009 Nov 28.
Published in final edited form as: Cell. 2008 Nov 20;135(5):933–947. doi: 10.1016/j.cell.2008.10.011

Figure 5. Dynamic monitoring of ER redox status and UPR activity during overexpression of secretory proteins.

Figure 5

(A–R) Time courses of eroGFP ratio or UPR-RFP metric histograms in wild-type (WT) or hrd1Δ cells expressing CPY, CPY*, CPY*-0000, CPY*-1cys, or CPY*-Cysless under control of the copper-inducible CUP1 promoter. Color represents percentage of cells at a given metric value and time point. The dashed gray line signifies time of CuSO4 (200µM or 500µM) addition.