Table 3.
Total number of women fulfilling different criteria for hereditary breast cancer syndromes in both study groups.
| Women reporting a FH1 of cancer in PCU2 (n = 885) | Women with a negative FH1 for cancer in PCU2 (n = 910) | |||
|---|---|---|---|---|
| n | % | n | % | |
| ASCO criteria for HBOC syndrome3 | 64 | 7.2 | 2 | 0.2 |
| High risk HBOC syndrome4 | 75 | 8.5 | 2 | 0.2 |
| HBCC criteria3 | 26 | 2.9 | 0 | 0.0 |
| LFL syndrome3 | 141 | 16.0 | 29 | 3.2 |
| HBC syndrome (overall)5 | 211 | 23.8 | 30 | 3.3 |
1 FH = Family History.
2 PCU = Primary Care Unit.
3 Criteria as described in materials and methods.
4 ASCO criteria and/or prior probability of a BRCA mutation ≥ 30% using Myriad mutation prevalence tables and the Penn II mutation prediction model.
5 Includes Hereditary Breast and Ovarian Cancer (HBOC), Hereditary Breast and Colorectal Cancer (HBCC) and Li-Fraumeni-like syndrome (LFL) criteria.