Table 4.
Ability of the FHS-7 to identify women with clinical criteria (family history) for hereditary breast cancer syndromes (n = 1795).
| Criteria | AUC (CI 95%) | Cut point = 1 | |||
|---|---|---|---|---|---|
| Sensitivity (CI 95%) | Specificity (CI 95%) | PPV1(CI 95%) | NPV2(CI 95%) | ||
| ASCO criteria3 | 0.85 (0.81–0.89) | 97.0 (91–100) | 52.0 (50–55) | 7.0 (6–9) | 100.0 (99–100) |
| High risk HBOC syndrome4 | 0.86 (0.82–0.90) | 97.0 (92–100) | 53.0 (50–55) | 8.0 (7–10) | 100.0 (99–100) |
| HBCC criteria3 | 0.86 (0.84–0.88) | 100.0 (89–100) | 51.0 (49–54) | 3.0 (2–4) | 100.0 |
| LFL syndrome3 | 0.72 (0.68–0.76) | 83.0 (77–88) | 54.0 (52–56) | 16.0 (14–18) | 97.0 (96–98) |
| HBC syndrome (overall)5 | 0.83 (0.81–0.85) | 88.0 (83–91) | 56.0 (54–59) | 24.0 (21–27) | 97.0 (95–98) |
1 PPV = positive predictive value.
2 NPV = negative predictive value.
3 Criteria as described in materials and methods.
4 ASCO criteria and/or estimated prior probability of a BRCA mutation ≥30%.
5 Includes Hereditary Breast and Ovarian Cancer (HBOC), Hereditary Breast and Colorectal Cancer (HBCC) and Li-Fraumeni-like syndrome (LFL) criteria.