Figure 1.

Experimental design. All animals underwent the diagrammed procedure daily for 8 days beginning 14 days following OBX or sham surgery. First, animals were placed in the open field arena (30 min pre-injection interval). Then, URB597 (0.3 mg/kg i.p.), URB597 (0.3 mg/kg i.p.) plus rimonabant (1 mg/kg i.p.), rimonabant alone (1 mg/kg i.p.) or vehicle (i.p.) was administered and rats were placed back into the arena (15 min pre-amphetamine interval). Amphetamine (1 mg/kg i.p.) was subsequently administered and rats were placed back into the arena (45 min post-amphetamine interval). Activity levels were monitored for each of the three phases described.