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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Synapse. 2009 Nov;63(11):941–950. doi: 10.1002/syn.20679

Figure 3.

Figure 3

Activity during the pre-amphetamine interval in sham-operated and olfactory bulbectomized rats. In sham animals, URB597 (0.3 mg/kg i.p.) decreased pre-amphetamine locomotor activity (a) on days 1–4 of the sensitization protocol. This effect was blocked by rimonabant (1 mg/kg i.p). P < 0.01 (ANOVA), *P < 0.05 for each comparison (Fisher's PLSD post hoc). (b) No changes in pre-amphetamine locomotor activity were observed on days 5–8 of testing. In sham animals, rimonabant (1 mg/kg i.p.) alone did not alter pre-amphetamine locomotor activity relative to vehicle during either the (c) first four or (d) last four days of testing. In OBX rats, URB597 (0.3 mg/kg i.p.) did not affect pre-amphetamine locomotor activity relative to vehicle during either the (e) first four or (f) last four days of testing. Data are Mean + SEM.