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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Synapse. 2009 Nov;63(11):941–950. doi: 10.1002/syn.20679

Figure 4.

Figure 4

Olfactory bulbectomy alters the development of amphetamine sensitization (a) Olfactory bulbectomy induces a heightened locomotor state in response to initial (day 1) amphetamine (1 mg/kg i.p.) administration P < 0.01 (ANOVA) *P < 0.05, ** P < 0.01 versus sham (t-test) (b) Sham animals develop a typical sensitization to repeated injections of amphetamine, as demonstrated by increased locomotor activity (P < 0.001 (Friedman's), +P < 0.05 versus day 1 (Dunn's multiple comparisons). By contrast, OBX animals are presensitized to amphetamine. Data are Mean + SEM.