Table 1.
Summary of AP parameters of control, singly- and co-transduced LV CMs. All values are means ± S.E.
| RMP (mV) |
MDP (mV) |
APD (ms) |
APD50 (ms) |
APD90 (ms) |
Phase 4 Length (ms) |
Phase 4 Slope (mV/s) |
Cycle Length (ms) |
Beating Rate (Beats/ min) |
|
|---|---|---|---|---|---|---|---|---|---|
|
Control
(17) |
-66.0 ± 0.7 |
-- | 387.2 ± 10.4 |
299.5 ± 12.0 |
357.3 ± 10.0 |
-- | -- | -- | -- |
|
Kir 2.1
(7) |
-69.7 ± 0.6 |
-- | 138.6 ± 17.6 |
116.1 ± 17.2 |
127.8 ± 17.8 |
-- | -- | -- | -- |
|
HCN1-ΔΔΔ
(10) |
-- | -55.8 ± 1.8 |
207.4 ± 9.4 |
166.9 ± 6.9 |
199.5 ± 8.7 |
88.3 ± 9.6 |
180.0 ± 20.0 |
343.7 ± 24.9 |
181.1 ± 13.1 |
|
HCN1-ΔΔΔ +
Kir2.1-WT (9) |
-- | -57.1 ± 1.0 |
107.37 ± 7.8 |
72.7 ± 7.8 |
97.3 ± 7.9 |
55.0 ± 4.5 |
280.0 ± 16.0 |
182.3 ± 6.8 |
320.0 ± 15.8 |
n numbers are given in bracket.