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. 2009 Sep 17;4(9):e7089. doi: 10.1371/journal.pone.0007089

Figure 2. Immunoglobulin Somatic Copy Number Variation.

Figure 2

The immunoglobulin loci at chromosomal subbands 2p11.2 (IGK), 14q32.3 (IGH) and 22q11.2 (IGL) showed acquired monoclonal alterations by the 244 K aCGH platform. The segmented rearrangements were identified by a stained rectangle and the individual oligonucleotides are identified by a bold dot. The Y axis is the chromosomal position, the X axis is the ratio (loss is to the left). A to D, S1: The IGH locus was rearranged in all cell lines (14/15) on the two chromosomes, with a specific pattern for each cell line. BL2 and BL31 have a t(8;14). A to D, S1: IGK gene rearrangements were detected in all cell lines and 8 have a clear biallelic rearrangement including LY91 the only t(2;8). A to D, S1: IGL loci somatic rearrangements were observed in only 10 cell lines (7 biallelics) including four cases of t(8;22) as in BLAL. Other cell lines are presented as supporting figures.