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. 2009 Jul 15;29(28):9104–9114. doi: 10.1523/JNEUROSCI.2250-09.2009

Figure 1.

Figure 1.

Deletion of Hsp70.1 and Hsp70.3 decreases survival in the R6/2 mouse, but not in mice infected with prions. A, Kaplan–Meier survival curve for the indicated genotypes [R6/2−/−;Hsp70+/+ (n = 21), R6/2tg/−;Hsp70+/+ (n = 18), R6/2−/−;Hsp70−/+ (n = 27), R6/2tg/−;Hsp70−/+ (n = 22), R6/2−/−;Hsp70−/−(n = 18), and R6/2tg/−;Hsp70−/− (n = 18)] demonstrates that the absence of Hsp70.1/3 significantly decreased survival of R6/2 mice (log rank: p = 0.033). No nontransgenic, Hsp70 heterozygous knock-out, or Hsp70 homozygous knock-out mice died during the 14 week time course. B, C, Kaplan–Meier survival curves for Hsp70+/+ (n = 11, and 12, respectively) and Hsp70−/− (n = 19) mice inoculated intracranially with 3.5 LC50 22L prion or 3.5 LC50 RML prion indicate that deletion of Hsp70.1/3 did not affect survival (log rank: p = 0.207 and 0.495, respectively).