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. 2008 Aug 14;14(30):4753–4762. doi: 10.3748/wjg.14.4753

Table 4.

Effects of herbal formulation on incidence, onset, duration and severity of hepatitis

ATT induced hepatitis outcome (Table 2) Control (n = 192) Trial (n = 316) P
Patients with raised AST (%) 27 (14) 2 (0.63) < 0.0001
Patients with raised S bilirubin (%) 17/27 (63) 0 < 0.0001
Mean onset of hepatitis symptomatic 49.12 ± 17.22 - < 0.0001
Mean onset of hepatitis asymptomatic 29.9 ± 17.63 39 ± 11.31 0.443
Mean onset of any hepatitis 42 ± 19.48 39 ± 11.31 0.776
Mean duration of raised AST 27.5 ± 7.25 21 < 0.0001
Hepatitis gradation
Grade-I 10 2 < 0.0001
Grade-II 9 0 < 0.0001
Grade-III 8 0 < 0.0001
Grade-IV 0 0
Reinstitution of ATT in patients (%) 22/27 (81.5) NA

P calculated by χ2 (categorical data) and two-sided Student’s t-test with Welch’s procedure (continuous data with unequal variance). NA: Not applicable.

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