Table 4.
Effects of herbal formulation on incidence, onset, duration and severity of hepatitis
ATT induced hepatitis outcome (Table 2) | Control (n = 192) | Trial (n = 316) | P |
Patients with raised AST (%) | 27 (14) | 2 (0.63) | < 0.0001 |
Patients with raised S bilirubin (%) | 17/27 (63) | 0 | < 0.0001 |
Mean onset of hepatitis symptomatic | 49.12 ± 17.22 | - | < 0.0001 |
Mean onset of hepatitis asymptomatic | 29.9 ± 17.63 | 39 ± 11.31 | 0.443 |
Mean onset of any hepatitis | 42 ± 19.48 | 39 ± 11.31 | 0.776 |
Mean duration of raised AST | 27.5 ± 7.25 | 21 | < 0.0001 |
Hepatitis gradation | |||
Grade-I | 10 | 2 | < 0.0001 |
Grade-II | 9 | 0 | < 0.0001 |
Grade-III | 8 | 0 | < 0.0001 |
Grade-IV | 0 | 0 | |
Reinstitution of ATT in patients (%) | 22/27 (81.5) | NA |
P calculated by χ2 (categorical data) and two-sided Student’s t-test with Welch’s procedure (continuous data with unequal variance). NA: Not applicable.