Table 1.

Lipoxins Counter-Regulate Cardinal Signs of Inflammation: Reduce Inflammation and Promote Resolution

Lipoxin and Aspirin-Triggered Lipoxin Actions	Reference
• Regulate leukocyte traffic	Colgan et al., 1993 (121)
- Stop PMN and eosinophil infiltration	Lee et al., 1989(122)
- Stimulate non-phlogistic monocyte recruitment	Maddox and Serhan, 1996 (113)
- Stimulate macrophage uptake of apoptotic PMN	Godson et al., 2000 (65)
• Redirect chemokine-cytokine axis
- Block EL-8, EL-1 gene expression	Gewirtz et al., 1998 (123)
- Block TNFα actions and release	Takano et al., 1997(124)
- Stimulate TGFβ	Bannenberg et al., 2005 (31)
• Reduce edema	Bandeira-Melo et al., 2000 (60)
- Regulate actions of histamine	Pouliot et al., 2000 (50)
	Menezes-de-Lima et al., 2006 (125)
• Block pain signals	Serhan et al., 2001 (64)
LX/LT regulate neuronal stem cells, proliferation and differentiation	Svensson et al., 2007 (63)
	Wada et al., 2006 (126)