Table 4.
Impact of E-Series And D-Series Resolvins in Disease Models or Organ Systems
| Disease Model | Actions | Mediator | References |
|---|---|---|---|
| Acute inflammation (murine peritonitis and dermal air pouch inflammation) | • Reduces PMN infiltration | Resolvin E1 | Serhan et al. (7, 8), Arita et al., (80) Bannenberg et al. (31) |
| • Upregulates CCR5 expression on late apoptotic human leukocytes | Resolvin E1 Protectin D1 ATL/LXA4 |
Ariel et al. (37) | |
| • Acts as “terminator” of chemokine signaling during resolution | Resolvin D1 | ||
| Colitis | • Decreases PMN recruitment and proinflammatory gene expression | Resolvin E1 | Arita et al. (82) |
| • Improves survival | |||
| • Reduces weight loss | |||
| • Genetically engineered fat-1 mice possess high levels of DHA and EPA, generate resolvins during colitis and demonstrate reduction in GI tissue damage | Resolvin E1 Resolvin D |
Hudert et al. (92) | |
| Periodontitis | • Reduces PMN infiltration, stops inflammation-induced tissue and bone loss | Resolvin E1 | Hasturk et al. (86) |
| Acute inflammation (murine peritonitis) | • Stops PMN infiltration | Resolvin E2 | Tjonahen et al. (84) |
| Acute inflammation (murine peritonitis) | • Stops PMN recruitment | Resolvin D1 | Serhan et al. (8) Sun et al, 2007 (81) |
| Microglial cells | • Reduces microglial cell cytokine expression in vitro | Hong et al. (9) | |
| Kidney | • Protects in renal ischemic injury by limiting PMN infiltration | Resolvin D1 and Protectin D1 | Duffield et al. (85) |
| • Regulates macrophages | |||
| Acute inflammation (murine peritonitis and dermal air pouch inflammation) | • Stops PMN recruitment | Resolvins D2, D3, D4 | Serhan et al., 2002 (8) |
| • Reduces peritonitis |