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Changes in plasma collagen IV levels mirror thinning of the basement membrane. We hypothesized that the thinning of the vascular basement membrane owing to vascular normalization would increase the level of circulating collagen IV. Indeed, cediranib significantly increased the plasma levels of collagen IV at day 2 (***P < .001 cediranib day 2 v control). Collagen IV levels were decreased at day 8 (**P < .01 cediranib day 2 v cediranib day 8).
