Table 2.
Randomized studies of adjuvant or neoadjuvant chemotherapies for SCC of the esophagus in Japan
| Study | Arm | n | DFS | P value | 5-yr OS (%) | P value |
|---|---|---|---|---|---|---|
| JCOG 920436 | S alone
S + CF |
122
120 |
45%* 55%* |
.037 | 52
61 |
.13 |
| JCOG 990737 | S + CF
CF + S |
166
164 |
2.0 yr† 3.0 yr† |
.044‡ | 38.4
60.1 |
.013 |
*
5-year disease-free survival rate
†
Median progression-free survival
‡
This P value is not significant
Abbreviations: SCC = squamous-cell carcinoma; JCOG = Japan Clinical Oncology Group; DFS = disease-free survival; OS = overall survival; S = surgery; CF= cisplatin + 5-fluorouracil