Table 3.
Definitive chemoradiotherapy vs. chemoradiotherapy followed by surgery for SCC of the esophagus
| Author | Arm | n | TRM (%) | 2-yr LCR (%) | P value | 2-yr survival (%) | P value |
|---|---|---|---|---|---|---|---|
| Stahl42 | CT (FLEP) + CRT (PE + 40 Gy) + S
CT (FLEP) + CRT (PE + 50–60 Gy) |
86
86 |
12.8
3.5 |
64.3
40.7 |
.003 | 39.9
35.4 |
NS (.007*) |
| FFCD43 | CRT (CF + 30–46 Gy) + S
CRT (CF + 45–66 Gy) |
129
130 |
9.3
0.8 |
66.4
57.0 |
.0014 | 33.6
39.8 |
NS (.03*) |
*
Test for noninferiority.
Abbreviations: SCC = squamous-cell carcinoma; TRM = treatment-related mortality; LCR = local control rate; CT = chemotherapy; CRT = chemoradiotherapy; S = surgery; FLEP = 5-fluorouracil + leucovorin + etoposide + cisplatin; PE = cisplatin + etoposide; CF = cisplatin + 5-fluorouracil; NS = not significant; FFCD = Fédération Francophone de la Cancérologie Digestive