Table 4.
Definitive chemoradiotherapy for SCC of the esophagus with T4 and/or M1 lymph node in Japan
| Study | Regimen | N | cCR rate (%) | MST | Leukopenia (%) (≥ grade 3) | Esophagitis (%) (≥ grade 3) |
|---|---|---|---|---|---|---|
| Ohtsu44 | CF + 60 Gy | 54 | 33.3 | 9 mo | 24.1 | 14.8 |
| JCOG 951645 | CF + 60 Gy | 60 | 15.0 | 10 mo | 33.3 | 3.3 |
| JCOG 990846 | NF + 60 Gy | 26 | 12.0 | 12 mo | 34.6 | 15.4 |
| KDOG 050147 | DCF + 61.2 Gy | 19 | 41.2 | 20 mo | 73.7 | 31.6 |
Abbreviations: SCC = squamous-cell carcinoma; cCR = clinical complete response; MST = median survival time; CF = cisplatin + 5-fluorouracil; NF = nedaplatin + 5-fluorouracil; DCF = docetaxel + cisplatin + 5-fluorouracil