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. Author manuscript; available in PMC: 2009 Dec 26.
Published in final edited form as: Cell. 2009 Jun 26;137(7):1213–1224. doi: 10.1016/j.cell.2009.03.049

Figure 2. Sterol Binding Pocket.

Figure 2

(A-C) The sigmaA-weighted 2Fo-Fc electron density map contoured at 1σ within the sterol binding pocket is shown in gray mesh for the apoNPC1(NTD) (A), the cholesterol-bound (B), and 25-HC-bound (C) forms. The binding pocket is essentially identical in apoNPC1(NTD) and the sterol bound forms. The binding pocket of apoNPC1(NTD) is occupied by 2 glycerol and 3 water molecules. NPC1(NTD) is colored gray, bound ligands are colored green, and water molecules are shown as red spheres.

(D) The internal surface of the binding pocket is shown in gray. Bound 25-HC is shown in green.