Genes involved in sulfur assimilation and biosynthesis of cysteine and glutathione. Asterisks and crosses indicate suppressors and enhancers of rust color, respectively. Genes not included in the screen are shown in parenthesis. Genes up-regulated in M22-CYS4::N123I or in M22-CYS4Δ are indicated by a triangle. Dotted lines show ubiquitin mediated negative regulation of Met4 by cysteine and positive regulation of the sulfur assimilation pathway by the Met4 complex.
Abbreviations: APS (adenosine 5′-phosphosulfate), PAPS (3′-phosphoadenosine-5′-phosphosulfate), SAM (S-adenosylmethionine), γ-GluCys (γ-glutamylcysteine), SAH (S-adenosylhomocysteine)