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. 2009 Jul 1;297(3):F662–F670. doi: 10.1152/ajprenal.00146.2009

Fig. 8.

Fig. 8.

Effect of PKC inhibition on 20-HETE-mediated ERK1/2 activation and effect of MEK1/2, c-Src, and EGFR inhibition on 5,14-20-HEDE-mediated activation of Akt. Western blot analyses were performed, and band intensities were graphed. A: changes in levels of phosphorylated form of ERK1/2 after 3-h incubation with 20 μM 20-HETE in the presence or absence of 4 μM bisindolylmaleimide I (BIS). B: changes in levels of phosphorylated form of Akt after 3-h incubation with 20 μM 5,14-20-HEDE in the presence or absence of an MEK (U0126, 10 μM), c-Src (SKI-606, 0.05 μM), or EGFR (EKB-569, 0.1 μM) inhibitor. *Significant difference between groups (P < 0.05).