Fig. 8.

Expression profiles of transient receptor potential vanilloid channel 5 (TRPV5), vitamin D receptor (VDR), Na⁺/Ca²⁺ exchanger 1 (NCX1), Na⁺-K⁺-2Cl⁻ cotransporter (NKCC), claudin-16, and 1,25-dihydroxy vitamin D₃-24-hydroxylase (CYP24A1) in mouse kidney at baseline (solid bars) on a Ca²⁺-replete diet and plain water and 8 h after ip 1,25(OH)₂D₃ administration (shaded bars). The mRNA quantified by real-time PCR was calculated as a fold-change ratio relative to the mRNA for GAPDH in wild-type (C⁺P⁺) mice. Data are means ± SE (n = 6–8/genotype per condition). *P < 0.05, baseline vs. 8 h within genotypes. Y P < 0.05, baseline vs. 8 h within C⁻P⁻. #P < 0.05, baseline comparison, C⁺P⁺ vs. C⁺P⁻. ⧫ P < 0.05, baseline comparison, C⁻P⁻ vs. C⁺P⁻. ¶P < 0.05, baseline comparison, C⁺P⁺ vs. C⁺P⁻. TP < 0.05; W P < 0.05; G P < 0.05, 8-h comparisons. There were no significant differences for other comparisons for which P values are not given.