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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Nat Neurosci. 2009 Aug 2;12(9):1114–1120. doi: 10.1038/nn.2361

Figure 4. Partial agonists decrease NMDA receptor open durations.

Figure 4

a, Single-channel current traces (2 s, displayed filtered at 1 kHz with downward openings) illustrate periods of activity recorded from patches containing just one active receptor, activated with the agonist combinations shown at left. Top panel illustrates switches between medium and low gating modes. Bottom panel illustrates periods of high-mode gating from the same records as in top panel, respectively. b, Histograms of open intervals for a record in each condition (events: Glu/Gly, 71,085; Ala/Glu, 283,797; SYM/Gly, 226,688) are overlaid with the probability density function (thick lines) and exponential components E1 – E4 (thin lines) calculated from the fits to the data from each patch with a 5C4O model. Insets show time constants and relative areas for the corresponding components. The fast component is present in all three modes whereas the three longer components correspond to the low-, medium- and high-mode, respectively.

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