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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Genes Chromosomes Cancer. 2009 Sep;48(9):786–794. doi: 10.1002/gcc.20683

Figure 4.

Figure 4

FISH mapping of breakpoints in tumor with t(14;15)(C2;D1). Left, Hybridization with BAC probe encompassing Tcra enhancer, showing signals on normal chromosome 14 (N 14) as well as on two copies of der(15) (Ab 15). In abnormal chromosome 15, Tcra enhancer is placed near Myc locus. Middle, Hybridization of BAC clone encompassing both Myc and Pvt1 to normal chromosome 15; in addition split signals are found on both der(14) (Ab 14) and der(15) (Ab 15). Right, Co-hybridization of BAC clones encompassing Tcra enhancer (green signals) and Myc (red signals) in lymphoma with t(14;15). Note adjacent Tcra and Myc signals on der(15) (Ab 15). N 14, normal 14; N 15, normal 15.