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. Author manuscript; available in PMC: 2010 May 27.
Published in final edited form as: Neuron. 2009 May 28;62(4):494–509. doi: 10.1016/j.neuron.2009.03.027

Figure 1. Regional and Neocortical Areal Gene Expression Profiling in the Mid-Fetal Human Brain.

Figure 1

(A) Human late mid-fetal brain illustrating locations of tissue samples microdissected from nine areas of neocortex (NCTX; including four areas of the prefrontal cortex [PFC]), hippocampus (HIP), striatum (STR), mediodorsal thalamus (THM), and cerebellum (CBL) from both sides of four mid-fetal brains. Dashed lines (i, ii) indicate levels of acetylcholine esterase-reacted coronal tissue sections.

(B) Comparison among NCTX, HIP, STR, THM, and CBL detected 76% of core genes expressed above background in at least one brain region. At a FDR of 10−5, 33% of these were DEX and 28% DAS between regions.

(C) Intra-NCTX analysis yielded fewer DEX and DAS genes, even at a relaxed threshold (FDR = 0.01).