TABLE 2.
Clinical and biochemical data from mice fed MCS and MCD formulas
| MCS-Sucrose | MCS-Starch | MCD-Sucrose | MCD-Starch | |
|---|---|---|---|---|
| Body weight change (%) | 21.8 ± 2.4 | 15.0 ± 2.5 | −29.1 ± 0.7b | −23.4 ± 0.8cd |
| Liver weight/body weight (%) | 4.8 ± 0.2 | 4.3 ± 0.1 | 6.3 ± 0.3b | 4.3 ± 0.5d |
| Adipose weight/body weight (%) | 4.6 ± 0.2 | 4.3 ± 0.3 | 0.5 ± 0.1b | 0.5 ± 0.1c |
| Serum TG (mg/dl) | 158.3 ± 12.2 | 135.9 ± 11.2 | 75.4 ± 2.1b | 84.1 ± 6.7c |
| Serum cholesterol (mg/dl) | 261.7 ± 18.6 | 162.8 ± 5.3a | 85.7 ± 2.8b | 101.6 ± 3.0cd |
| Serum glucose (mg/dl) | 385.6 ± 42.3 | 284.3 ± 11.1 | 173.8 ± 20.0b | 209.2 ± 9.7c |
| Serum insulin (ng/ml) | 1.04 ± 0.28 | 1.07 ± 0.23 | 0.2 ± 0.1b | 0.1 ± 0.0c |
| QUICKI | 0.18 ± 0.0 | 0.19 ± 0.01 | 0.23 ± 0.01b | 0.23 ± 0.0c |
| Serum leptin (ng/ml) | 26.68 ± 3.96 | 16.88 ± 2.65 | 0.3 ± 0.1b | 0.2 ± 0.1c |
| Serum adiponectin (μg/ml) | 4.2 ± 0.2 | 4.3 ± 0.2 | 5.3 ± 0.4b | 4.7 ± 0.3 |
| Hepatic TG (mg/g liver) | 42.9 ± 8.9 | 23.2 ± 3.3 | 115.2 ± 11.3b | 34.4 ± 2.9cd |
| Serum ALT (IU/l) | 56.2 ± 6.2 | 59.6 ± 7.0 | 571.3 ± 74.7b | 93.0 ± 8.8cc |
Values represent mean ± SEM for n = 10. QUICKI, qualitative insulin sensitivity check index = (log insulinpg/ml + log glucosemg/dl)−1.
a
P < 0.05 for MCS-starch versus MCS-sucrose.
b
P < 0.05 for MCD-sucrose versus MCS-sucrose.
c
P < 0.05 for MCD-starch versus MCS-starch.
d
P < 0.05 for MCD-starch versus MCD-sucrose.