. 2009 Oct;50(10):2095–2102. doi: 10.1194/jlr.M900236-JLR200

TABLE 4.

Effects of simvastatin (5 μM) and pravastatin (10 μM) on gene expression in primary human astrocytes and SK-N-SH cells

	Gene	Simvastatin	Pravastatin
Astrocytes	ABCA1	−78.6 ± 9.8^a	−54.25 ± 23.1^a
	PLTP	−31.5 ± 11.8^a	−42.9 ± 24.2^a
	APOE	−23.1 ± 10.2^a	−26.9 ± 25.1
	MAPT	−49.5 ± 4.9^a	–40.8 ± 3.8^a
	CDK5	−6.4 ± 0.7	−14.6 ± 1.8^a
	GSK3β	−3.7 ± 15.3	3.4 ± 5.0
	APP	−4.3 ± 5.4	−1.6 ± 9.8
	DAB1	4.4 ± 24.7	−20.72 ± 11.1^a
SK-N-SH	ABCA1	−96.8 ± 2.4^a	−69.8 ± 15.5^a
	PLTP	−29.6 ± 6.1^a	−2.9 ± 21.2
	MAPT	40.9 ± 11.1^a	19.3 ± 4.7^a
	CDK5	36.4 ± 11.8^a	1.5 ± 6.4
	GSK3β	20.4 ± 7.9^a	4.7 ± 9.9
	APP	16.6 ± 14.7	15.2 ± 4.6^a
	DAB1	−10.9 ± 34.0	−2.2 ± 19.3

Primary human astrocytes used in these experiments were obtained from four different donors. Data are presented as average percentage change ± SD in at least three consecutive experiments performed in triplicate and assayed in three technical replicates.

P < 0.05 represents statistically significant difference between control and statin data, by t-test, that was replicated in each individual experiment.