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. 2009 Jul 10;297(3):L475–L486. doi: 10.1152/ajplung.00060.2009

Fig. 8.

Fig. 8.

NFATc3 activation increases mouse sGC-α1 promoter activity in HEK-293 cells. A: cells overexpressing NFATc3 were cotransfected with WT sGC-luc or sGC promoter mutated at site 3 (sGC-MUT-luc) and Renilla-luc plasmids. NFATc was activated with 1 μM Io for 24 h ± 1 μM CsA. B: NFATc3-overexpressing HEK cells were cotransfected with a dominant negative NFAT plasmid (DN) ± 1 μM Io for 24 h. Total DNA plasmid was maintained constant. Values are means ± SE; n = 6. *P < 0.05 vs. basal. #P < 0.05 vs. sGC-luc.