Table 1.
Anthropometric and renal characteristics of 20- to 22-wk-old and 52- to 55-wk-old lean wild-type (WT) and obese melanocortin-4 receptor-deficient (MC4R−/−) mice
| Parameters |
20–22 wk old |
52–55 wk old
|
||
|---|---|---|---|---|
| WT | MC4R | WT | MC4R | |
| Food intake, g | 3.5±0.4 | 5.0±0.3* | 4.0±0.2 | 5.8±0.3* |
| Body weight, g | 29±1 | 48±2* | 39±1 | 63±1* |
| Plasma glucose, mM | 9±0.3 | 11±0.2 | 15±0.5 | 14±1.5 |
| Plasma leptin, ng/ml | 3±1 | 47±13* | 18±4 | 82±11* |
| Plasma insulin, ng/ml | 1.33±0.58 | 4.80±1.88* | 0.72±0.12 | 2.4±0.68* |
| Total kidney weight, g | 0.33±0.02 | 0.39±0.02* | 0.46±0.01 | 0.54±0.02* |
| Visceral pad fat | 0.4±0.1 | 3.7±0.2 | 2.1±0.2 | 4.3±0.2* |
Values are means ± SE; n = 6–7 per group.
*
P < 0.05 compared with WT mice.