Fig. 1.

Effects of Indinavir treatment and bilirubin infusion on plasma bilirubin levels (A) and conjugated/total bilirubin levels (B). Mice were treated with Indinavir (500 mg·kg⁻¹·day⁻¹, oral gavage) for 5 days or directly infused with 37.2 mg·kg⁻¹·day⁻¹ bilirubin, and then the plasma levels of unconjugated and conjugated bilirubin were determined using a commercially available kit. Both Indinavir treatment and bilirubin infusion resulted in increased unconjugated bilirubin levels in the plasma, whereas the percentage of conjugated bilirubin levels was decreased in Indinavir-treated mice; n = 20 control, 4 Indinavir, 4 bilirubin mice. *P < 0.05 vs. control.