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. 2009 Jul 9;297(3):G539–G549. doi: 10.1152/ajpgi.00064.2009

Fig. 3.

Fig. 3.

Effect of anandamide (1 μM) added to the peripheral motor compartments on ascending contraction (left) and descending relaxation (right) alone and in the presence of the CB-1 receptor antagonist AM-251 (0.1 μM) and the TRPV1 receptor antagonist resiniferatoxin (RTX; 0.1 μM). ○ and solid line, Control responses to mucosal stroking in the absence of added agents; ▴ and solid line; response in the presence of anandamide alone; • and dashed line; response in the presence of anandamide and AM-251; ▾ or ♦ and dashed line, response in the presence of anandamide and RTX. Separate colons and animals were used for measuring the responses to anandamide plus each antagonist, for addition to orad peripheral motor compartment (ascending contraction), and for addition to caudad peripheral motor compartment (descending relaxation). Values are means ± SE of 3–6 experiments. *Significance of P < 0.05.