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. 2009 Aug 19;10:384. doi: 10.1186/1471-2164-10-384

Table 2.

Differentially expressed genes involved in cholesterol homeostasis in mouse liver after TCPOBOP treatment

TCPOBOP + normal chow diet Vehicle + cholesterol diet TCPOBOP + cholesterol diet
Gene Symbol Gene Description Log2 ratio p-value Log2 ratio p-value Log2 ratio p-value
Cholesterol biosynthesis
Sc4mol Sterol-C4-methyl oxidase-like nc nc -2.50 0.000 1.85 0.001
Cyp51 Cytochrome P450, 51a1 nc nc -1.86 0.001 1.27 0.008
Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 nc nc -1.79 0.001 1.20 0.015
Fdps Farnesyl diphosphate synthase 1 nc nc -1.73 0.001 0.99 0.026
Fdft1 Farnesyl diphosphate farnesyl transferase 1, Squalene synthase nc nc -1.69 0.000 1.08 0.006
Nsdhl NAD(P) dependent steroid dehydrogenase-like nc nc -1.35 0.004 0.99 0.033
Lss Lanosterol synthase 0.60 0.033 -1.31 0.000 0.81 0.012
Mvd Mevalonate (diphospho) decarboxylase nc nc -1.27 0.002 0.88 0.017
Mvk Mevalonate kinase nc nc -1.18 0.001 0.86 0.010
Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase 0.99 0.001 -1.14 0.001 1.09 0.008
Sqle Squalene epoxidase 0.49 0.014 -1.11 0.014 nc nc
Dhcr24 24-dehydrocholesterol reductase nc nc -0.57 0.019 0.54 0.018
Dhcr7 7-dehydrocholesterol reductase nc nc -0.36 0.049 nc nc
Idi1 Isopentenyl-diphosphate delta isomerase nc nc 0.39 0.003 nc nc
Sc5d Sterol-C5-desaturase homolog 0.36 0.029 nc nc nc nc
SREBP signaling pathway
Insig1 Insulin induced gene 1 0.82 0.000 nc nc nc nc
Mbtps1 Membrane-bound transcription factor peptidase, site 1 1.72 0.000 nc nc 2.06 0.003
Insig2 Insulin induced gene 2 1.94 0.000 0.25 0.038 1.24 0.000
Bile acid synthesis
Cyp8b1 Cytochrome P450, 8b1 -2.16 0.000 nc nc -0.67 0.036
Cyp7b1 Cytochrome P450, 7b1 0.21 0.014 nc nc nc nc
Cyp27a1 Cytochrome P450, 27a1 0.73 0.000 nc nc 0.46 0.028
Cyp39a1 Cytochrome P450, 39a1 1.06 0.000 nc nc 0.91 0.000
Lipid transport
Apoa5 Apolipoprotein A-V -0.57 0.013 nc nc -0.45 0.039
Apoe Apolipoprotein E -0.38 0.019 nc nc -0.46 0.022
Ldlr Low density lipoprotein receptor 0.32 0.017 -0.38 0.037 0.42 0.039
Apoa4 Apolipoprotein A-IV 2.23 0.000 1.09 0.000 1.00 0.001
Transporters
Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.39 0.024 0.18 0.040 -0.38 0.015
Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.46 0.001 0.68 0.000 nc nc
Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.92 0.000 nc nc 0.89 0.000
Slco1a4 Solute carrier organic anion transporter family, member 1a4 1.04 0.000 -0.98 0.000 1.66 0.000
Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.29 0.000 -0.76 0.003 2.06 0.000
Abcg8 ATP-binding cassette, sub-family G (WHITE), member 8 nc nc nc nc -1.02 0.006
Abcg5 ATP-binding cassette, sub-family G (WHITE), member 5 nc nc nc nc -0.87 0.008
Slco2b1 Solute carrier organic anion transporter family, member 2b1 -0.40 0.001 0.25 0.009 nc nc
Other
Scarb1 Scavenger receptor class B, member 1 -0.87 0.000 0.31 0.003 -0.88 0.000
Acat2 Acetyl-Coenzyme A acetyltransferase 2 -0.31 0.010 nc nc -0.33 0.019
Lip1 Lysosomal acid lipase 1 0.49 0.000 0.38 0.002 0.28 0.043
Saa2 Serum amyloid A 2 -3.60 0.000 nc nc -3.28 0.001
Saa1 Serum amyloid A 1 -3.52 0.000 nc nc -3.22 0.001
Saa3 Serum amyloid A 3 -3.39 0.000 nc nc -2.87 0.001

Differentially expressed genes involved in cholesterol homeostasis in mouse liver after TCPOBOP treatment or cholesterol diet as detected by the Steroltalk microarray. Data represent log2 ratios of TCPOBOP treated versus vehicle treated on the same diet (standard or cholesterol) and vehicle treated group on cholesterol diet versus standard diet. Six animals per group were used and p-value was calculated using t-test as implemented in BRB-Array Tools. GeneBank accession numbers are available in Additional file 1. nc – no change.