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. 2009 Aug 19;10:384. doi: 10.1186/1471-2164-10-384

Table 4.

Differentially expressed genes involved in glucose and triglyceride metabolism in mouse liver after TCPOBOP treatment

TCPOBOP + normal chow diet Vehicle + cholesterol diet TCPOBOP + cholesterol diet
Gene Symbol Gene Description Log2 ratio p-value Log2 ratio p-value Log2 ratio p-value
Carbohydrate metabolism
Pck1 Phosphoenolpyruvate carboxykinase 1, cytosolic -0.47 0.042 nc nc -0.39 0.039
Pdhb Pyruvate dehydrogenase (lipoamide) beta 0.61 0.000 0.33 0.005 0.43 0.014
G6Pase Glucose-6-phosphatase catalytic nc nc 1.00 0.005 -1.26 0.000
Gapdh Glyceraldehyde-3-phosphate dehydrogenase nc nc 0.49 0.016 nc nc
Fatty acid metabolism
Cpt1a Carnitine palmitoyltransferase 1a, liver -0.81 0.000 nc nc -0.38 0.004
Hmgcl 3-hydroxy-3-methylglutaryl-Coenzyme A lyase 0.31 0.008 -0.53 0.001 0.64 0.003
Fasn Fatty acid synthase 0.58 0.007 nc nc nc nc
Scd1 Stearoyl-Coenzyme A desaturase 1 nc nc 1.40 0.004 -1.32 0.018
Cyp4f14 Cytochrome P450, 4f14 nc nc 0.98 0.000 -0.72 0.000
Transcription regulators
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha -1.17 0.000 nc nc -0.99 0.000
Sirt1 Sirtuin 1, silent mating type information regulation 2, homolog 1 -0.40 0.010 nc nc nc nc
Foxa2 Forkhead box A2 -0.22 0.049 nc nc nc nc
Mlxipl MLX interacting protein-like, old Wbscr14 or Chrebp 0.94 0.000 1.05 0.000 0.32 0.047
Crem CAMP responsive element modulator nc nc 0.35 0.002 -0.35 0.016
Ppara Peroxisome proliferator activated receptor alpha -0.84 0.000 0.53 0.035 -0.93 0.000
Pparg Peroxisome proliferator activated receptor gamma -0.83 0.005 nc nc nc nc
Transporters
Slc2a4 Solute carrier family 2 (facilitated glucose transporter), member 4 -0.43 0.000 nc nc nc nc
Slc2a1 Solute carrier family 2 (facilitated glucose transporter), member 1 0.37 0.001 nc nc 0.32 0.011
Cell signaling
Ppp1r3c Protein phosphatase 1, regulatory (inhibitor) subunit 3C -3.47 0.000 -0.39 0.015 -2.64 0.000
Igf1 Insulin-like growth factor 1 -1.08 0.000 0.69 0.000 -1.37 0.000
Adipor2 Adiponectin receptor 2 -0.85 0.000 nc nc -0.80 0.001

Differentially expressed genes involved in glucose and triglyceride metabolism in mouse liver after TCPOBOP treatment or cholesterol diet as detected by the Steroltalk microarray. Data represent log2 ratios of TCPOBOP treated versus vehicle treated on the same diet (standard or cholesterol) and vehicle treated group on cholesterol diet versus standard diet. Six animals per group were used and p-value was calculated using t-test as implemented in BRB-Array Tools. GeneBank accession numbers and are available in Additional file 1. nc – no change.