Table 5.
Gene annotation of differentially expressed genes
| KEGG pathway | No of genes | Genes |
| TCPOBOP in normal mouse liver | ||
| Adipocytokine signaling pathway | 10 | Pck1, Adipor1, Ppara, Mapk9, Cpt1a, Slc2a1, Nfkbia, Stat3, Adipor2, Slc2a4 |
| Metabolism of xenobiotics by cytochrome P450 | 8 | Cyp1a2, Cyp2b13, Cyp2b10, Cyp2c40, Cyp2e1, Cyp2b9, Cyp3a25, Cyp3a13 |
| PPAR signaling pathway | 7 | Pck1, Cyp8b1, Ppara, Apoa5, Cpt1a, Cyp27a1, Pparg |
| ABC transporters – General | 6 | Abcc2, Abcb11, Abca1, Abcc1, Abcb4, Abcc3 |
| Complement and coagulation cascade | 6 | Hc, C2, C4bp, Serping1, C9, Fgb |
| Insulin signaling pathway | 5 | Pck1, Fasn, Mapk9, Ppp1r3c, Slc2a4 |
| Arachidonic acid metabolism | 5 | Cyp2b13, Cyp2b10, Cyp2c40, Cyp2e1, Cyp2b9 |
| Linoleic acid metabolism | 5 | Cyp1a2, Cyp2c40, Cyp2e1, Cyp3a25, Cyp3a13 |
| Biosynthesis of steroids | 4 | Lss, Sqle, Hmgcr, Sc5d |
| Cholesterol diet | ||
| Biosynthesis of steroids | 13 | Dhcr7, Lss, Mvk, Nsdhl, Idi1, Cyp51a1, Sqle, Hmgcr, Mvd, Fdps, Fdft1, Dhcr24, Sc4mol |
| Metabolism of xenobiotics by cytochrome P450 | 4 | Cyp2f2, Cyp2c40, Cyp3a25, Cyp3a13 |
| PPAR signaling pathway | 4 | Ppara, Scd1, Scp2, Apoc3 |
| Terpenoid metabolism | 4 | Idi1, Sqle, Fdps, Fdft1 |
| TCPOBOP in hyperlipidemic mouse liver | ||
| Biosynthesis of steroids | 10 | Lss, Mvk, Nsdhl, Cyp51a1, Hmgcr, Mvd, Fdps, Fdft1, Dhcr24, Sc4mol |
| PPAR signaling pathway | 7 | Pck1, Cyp8b1, Ppara, Apoa5, Scd1, Cpt1a, Cyp27a1 |
| Metabolism of xenobiotics by cytochrome P450 | 7 | Cyp1a2, Cyp2b13, Cyp2b10, Cyp2c40, Cyp2b9, Cyp3a25, Cyp3a13 |
| Adipocytokine signaling pathway | 6 | Pck1, Ppara, Cpt1a, Slc2a1, Adipor2, Mapk8 |
| Arachidonic acid metabolism | 6 | Cyp2b13, Cyp2b10, Cyp2c40, Cyp2b9, Cyp4f14 |
| ABC transporters – General | 5 | Abcg5, Abcc2, Abca1, Abcc3, Abcg8 |
| Linoleic acid metabolism | 5 | Pla2g6, Cyp1a2, Cyp2c40, Cyp3a25, Cyp3a13 |
| Complement and coagulation cascade | 5 | C2, C4bp, Serping1, C9, Fgb |
| Butanoate metabolism | 4 | Hmgcl, Hmgcs1, Acat2, Pdhb |
Gene annotation of differentially expressed genes using GeneCodis software and KEGG pathways, showing only pathways with at least four genes. Down-regulated genes are underlined.