Fig. 2.

XMRV proteins detected in infected cultured cells and in prostate cancer tissue by IHC, using anti-XMRV antiserum. Counterstaining with hematoxylin reveals blue nuclei. (A and B) XMRV-infected cells: 100% infected (A) and 1% infected (B). (C) Cultured infected cells at higher magnification show cytoplasmic granular staining, represented diagrammatically in C1 (arrowhead, granules). (D–F) Human prostate cancers with clusters of malignant epithelial cells (E), with Inset at higher magnification (E1). Granular staining pattern seen at higher magnification. (F and F1) Adjacent section stained with preimmune serum from the same rabbit. N, nucleus; n, nucleolus.