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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Adv Appl Microbiol. 2009;68:133–216. doi: 10.1016/S0065-2164(09)01204-0

Figure 4.

Figure 4

Model of capsule growth and capsule rearrangements during budding in C. neoformans (From Zaragoza et al, 2006b). A. Model of capsule growth. After capsule enlarges a newly synthesized capsule (light green) accumulates at the edge of the capsule, with the old capsule (light blue) remaining close to the cell wall. B. Model of adaptation to non-capsule growth inducing conditions. Cells with large capsules, when transferred to a medium that does not induce capsule growth, cannot degrade the capsule, but the new emerging buds have a small capsule. C. Rearrangements of the capsule during budding. Panels 1–6 illustrate schematically different stages of budding. When bud arises, a dimple and a tunnel are formed (2, 3), which allows the separation of the bud. Bud growth is accompanied by capsule growth in the bud (3, 4). Capsule of the mother cell closes as the bud separates from the mother cell, at the same time that the bud completes the capsule without taking any polysaccharide of the mother cell (5), which will allow for the complete separation of the bud (6).