Fig. 4.
Ectopic expression of PF increases cell sensitivity to camptothecin. (A) Verification of PF expression by Western blot analysis. Whole cell lysate of RD/Vector or RD/PF cells were analyzed by Western blotting with FKHR-specific antibody and anti β-actin antibody (as loading control). (B) Cell proliferation assay. RD/Vector or RD/PF cells were treated with 0.1% DMSO or 150 nM camptothecin for 48 h. Cell viability was determined by the CellTiter-Glo® assay. Data represent 3 independent experiments, each performed in triplicate. Error bars indicate the standard error of the mean. Difference between the 2 cell lines was significant (p < 0.001) (***).