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Inhibition of UVB-induced MMP-1 and -3 secretions from HDF by cordycepin. Cells were stimulated with UVB (25 mJ/cm2) and the indicated concentrations of cordycepin for 24 h. Level of MMP-1 and -3 in culture media was measured using a commercially available ELISA kit as described in Methods. Each value represents the mean ± SEM of three independent experiments. *P < 0.01 vs. untreated control, #P < 0.01 vs. UVB.
