Skip to main content
. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: J Immunol. 2009 Mar 1;182(5):3131–3138. doi: 10.4049/jimmunol.0803637

FIGURE 2. T cells are involved in the development of autoimmune and inflammatory disorders in p105−/− mice.

FIGURE 2

A, Colons and Lungs from p105−/− mice on Rag1+/+ (p105−/−/Rag1+/+) or Rag1 knockout (p105−/−/Rag1−/−) background were subjected to histology analyses. Colonic patches (upper) and lung infiltrations (lower) are indicated by arrowheads, which were detected in p105−/−/Rag1+/+ mice but not in p105−/−/Rag1KO mice. Original magnification, x20. B, Induction of inflammatory cell infiltration by adoptively transferred p105−/− T cells. Rag1−/− mice (4–6 weeks old) were intravenously injected with T cells isolated from the mesenteric lymph nodes of WT or p105−/− mice. After 6 weeks, the recipient mice were sacrificed for histology analyses of lymphocyte infiltration in the colon. An arrowhead indicates a colonic patch detected in a recipient of p105−/− T cells. Data are representative of three mice per group. Original magnification, x20. C, RNA samples were isolated from colons of the adoptively transferred mice described in B and subjected to real-time PCR analyses to detect the relative mRNA expression of the indicated genes.

HHS Vulnerability Disclosure