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. Author manuscript; available in PMC: 2009 Sep 9.
Published in final edited form as: Laryngoscope. 2009 Aug;119(8):1510–1517. doi: 10.1002/lary.20294

TABLE II.

Common Adverse Events.

Number of Patients (%)
Grade 2 Grade 3 Grade 4 Grade 5
Following induction chemotherapy (n = 36)
Neutropenia 1 (3) 2 (5) 1 (1) 0
     Febrile neutropenia 0 0 0 0
     Leukopenia 2 (5) 4 (11) 1 (3) 0
     Anemia 6 (17) 0 0 0
     Thrombocytopenia 0 1 (3) 0 0
     Diarrhea 3 (8) 0 0 0
     Mucositis 3 (8) 7 (19) 1 (3) 0
     Nausea 2 (5) 0 0 0
     Vomiting 1 (3) 0 0 0
     Tinnitus 0 0 0 0
     Sensory neuropathy 0 0 0 0
During chemoradiation (n = 27)
     Neutropenia 1 (4) 1 (4) 0 0
     Febrile neutropenia 0 0 0 0
     Leukopenia 4 (15) 4 (15) 0 0
     Anemia 4 (15) 3 (11) 0 0
     Thrombocytopenia 3 (9) 3 (9) 0 0
     Diarrhea 0 0 0 0
     Mucositis 14 (52) 13 (48) 0 0
     Nausea 1 (4) 2 (7) 0 0
     Vomiting 1 (4) 3 (11) 0 0
     Sensory neuropathy 1 (4) 0 0 0
     Tinnitus 0 0 0 0
     Creatinine 3 (4) 0 0 0
Following adjuvant chemotherapy (n = 8)
     Neutropenia 0 0 0 0
     Febrile neutropenia 0 0 1 (13) 0
     Leukopenia 1 (13) 0 1 (13) 0
     Anemia 5 (62) 2 (25) 0 0
     Thrombocytopenia 0 0 0 0
     Sensory neuropathy 0 0 0 0