Table 1.
enzyme | IC50 (nM)a | fold-resistance (range)b | p-valuec |
---|---|---|---|
WT | 87 ± 12 | ||
AZTR | 125 ± 16 | 1.4 (1.2-1.7) | 0.11 |
AZTR/Q509L | 113 ± 11 | 1.3 (1.1-1.6) | 0.18 |
Reported values are the mean and standard error of 3-6 independent experiments.
Upper and lower limits were determined for fold-resistance on the basis of standard errors calculated for IC50 values.
Mutant RT IC50 values were compared to WT IC50 for statistically significant differences using a two-sided Student's t-test.