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. Author manuscript; available in PMC: 2009 Dec 30.
Published in final edited form as: Biochemistry. 2008 Dec 30;47(52):14020–14027. doi: 10.1021/bi8014778

Table 1.

Inhibition of WT, AZTR, and AZTR/Q509L HIV-1 RT by AZT-TP

enzyme IC50 (nM)a fold-resistance (range)b p-valuec
WT 87 ± 12
AZTR 125 ± 16 1.4 (1.2-1.7) 0.11
AZTR/Q509L 113 ± 11 1.3 (1.1-1.6) 0.18
a

Reported values are the mean and standard error of 3-6 independent experiments.

b

Upper and lower limits were determined for fold-resistance on the basis of standard errors calculated for IC50 values.

c

Mutant RT IC50 values were compared to WT IC50 for statistically significant differences using a two-sided Student's t-test.