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The xt2 null mice have increased levels of neutral amino acids in urine and a slight but not significant decrease of plasma glycine and l-arginine. Plasma (A) and urine (B) of xt2+/+ and xt2−/− mice were deproteinized and analyzed by HPLC. Amino acids are shown in single-letter code. Bars, mean values ± S.E.; n = 7 (A) and n = 6 (B) mice/genotype. *, p < 0.05; **, p < 0.01; ***, p < 0.001. ns, not significant; ND, not determined.
