FIGURE 5.
Expression of oxidative, lipolytic, and thermogenic genes is altered in peripheral tissues of SKO mice. A–D, expression of genes involved in uncoupling, lipid uptake, lipolysis, and fatty acid oxidation was measured in liver (A), skeletal muscle (B), WAT (C), and BAT (D) of chow- or HFD-fed SKO and Lox mice. Data are presented as means ± S.E. *, p < 0.05 versus Lox counterparts. Aox, acyl-CoA oxidase; β3-AR, β3-adrenergic receptor; Cpt-1, carnitine palmitoyltransferase-1; Dio2, type II iodothyronine deiodinase; Hsl, hormone-sensitive lipase; Lcad, long-chain acyl-CoA dehydrogenase; Lpl, lipoprotein lipase; Pgc-1α, PPAR-γ co activator-1α; Ucp, uncoupling protein.