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. 2009 May 28;284(30):20364–20374. doi: 10.1074/jbc.M109.006569

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Age-related changes in the levels of mitochondrial and cytosolic oxidative damage. Levels of protein carbonyls were quantified in mitochondrial (A) and cytosolic (B) extracts from young (3 months), middle-aged (12 months, cytosolic only), and old (23 months) Mclk1^+/+ and Mclk1^+/− isogenic F1 males from a 129S6 X BALB/c cross. Data are the means ± S.E. of 8–10 animals. The asterisk denotes statistical significance of the differences between 3- and 23-month-old Mclk1^+/+ as well as between 3- and 23-month-old Mclk1^+/− animals; p < 0.05.