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. 2009 May 28;284(30):20364–20374. doi: 10.1074/jbc.M109.006569

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — 2-Fold reduction of Mclk1 expression significantly reduces the levels of systemic oxidative damage observed in Sod2^+/− mice. Mclk1 heterozygosity reduced the levels of systemic oxidative stress as revealed by an increased mitochondrial aconitase activity (A) as well as by a reduction in the amounts of cytosolic lipid peroxidation (B), cytosolic carbonyls (C), and plasmatic 8-OHdG (D) observed in 15-month-old Sod2^+/− Mclk1^+/− mutants. Each point or bar in the graphs represents the mean ± S.E. of 8–10 animals. The statistical significance of the differences between 3- and 15-month-old Sod2^+/− Mclk1^+/− animals (A) or between Sod2^+/− and Sod2^+/− Mclk1^+/− animals (B–D) were shown on the respective graphs; p < 0.05.