TABLE 1.

Genes with signaling and/or neuronal functions that are commonly regulated by NAMPT, NMNAT-1, and SIRT1 in MCF-7 cells

Gene symbol	Gene name	Functions
ATXN10	Ataxin 10	Pentanucleotide repeat expansions in the ATXN10 gene lead to spinocerebellar ataxia type 10 (SCA10) (57).
NAT1	N-Acetyltransferase 1	NAT1 protein is a subunit of an N-acetyltransferase complex that co-localizes with microtubules in dendrites and regulates dendrite development (58). The same complex also associates with ß-amyloid precursor protein and regulates amyloid ß-protein generation (59).
NELL2	NEL-like 2	NELL2 encodes a neuron-specific epidermal growth factor-like protein that promotes neuronal differentiation (60).
NPY1R	Neuropeptide Y receptor type Y1	NPY1R protein is a receptor for neuropeptide Y, one of the most abundant neuropeptides in the mammalian nervous system (61).
PEG10	Paternally expressed 10	PEG10 is an imprinted gene (62). PEG10 protein functions in part by interacting with members of the transforming growth factor β receptor family. PEG10 transcript is abundant in the brain. Overexpression of PEG10 and activin receptor-like kinase 1 (Alk1) in different cell types induces a neuronal-like morphology (63).
SOCS2	Suppressor of cytokine signaling 2	SOCS2 protein suppresses cytokine signaling through interactions with the cytoplasmic domain of insulin-like growth factor-1 receptor (64). In the nervous system, SOCS2 regulates neuronal differentiation and neurite outgrowth (65).
TFPI	Tissue factor pathway inhibitor	TFPI encodes a protease inhibitor that regulates the tissue factor-dependent pathway of blood coagulation (66). TFPI protein is elevated in frontal cortex samples from Alzheimer disease brains and associates with amyloid ß-containing senile plaques (67).
TGFB2	Transforming growth factor β2	TGFB2 encodes a cytokine that regulates many functions, e.g. tumor-suppression, cell invasion, immune regulation, and microenvironment modification (68).
TMSNB	Thymosin β identified in neuroblastoma cells	TMSNB was first identified in neuroblastoma cells. It binds to and sequesters actin monomers and, therefore, inhibits actin polymerization (69).