Table 3.
Odds ratios* for all-cause dementia by CRP group
| All Subjects | Men | Women | ||||
|---|---|---|---|---|---|---|
| Total N | 294 | 96 | 198 | |||
|
| ||||||
| N with all-cause dementia | 66 | 10 | 56 | |||
|
| ||||||
| Age-Adjusted Model | OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value |
|
| ||||||
| Undetectable (< 0.5 mg/dL) | 1.00 | -- | 1.00 | -- | 1.00 | -- |
| Detectable (0.5 – 0.7 mg/dL) | 3.4 (1.4 – 7.9) | 0.005 | 2.1 (0.36 – 12.4) | 0.41 | 4.1 (1.5 – 11.3) | 0.006 |
| Elevated (≥ 0.8 mg/dL) | 4.5 (1.9 – 10.6) | 0.001 | 2.7 (0.45 – 16.1) | 0.28 | 5.5 (2.0 – 15.1) | 0.001 |
|
| ||||||
| Fully-Adjusted Model† | OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value |
|
| ||||||
| Undetectable (< 0.5 mg/dL) | 1.00 | -- | 1.00 | -- | 1.00 | -- |
| Detectable (0.5 – 0.7 mg/dL) | 3.0 (1.2 – 7.3) | 0.02 | 1.9 (0.27 – 13.2) | 0.52 | 4.6 (1.4 – 14.9) | 0.01 |
| Elevated (≥ 0.8 mg/dL) | 5.0 (1.9 – 12.9) | 0.001 | 3.3 (0.46 – 24.3) | 0.23 | 8.1 (2.4 – 27.3) | 0.001 |
*
Odds ratios (OR), 95% confidence intervals (CI), and p-values were computed using logistic regression. Covariates included in the adjusted model were age, gender, education, APOE4 status, aspirin use, history of transient ischemic attack (TIA), congestive heart failure, or coronary artery disease. Odds ratios for women were also adjusted for current estrogen use.
†
In all subjects, age and gender were significant covariates in the adjusted model. In men, the only significant covariate was age, whereas in women, age, APOE4 status, or a history of TIA were associated with significantly increased odds of all-cause dementia.