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. Author manuscript; available in PMC: 2010 Jun 4.
Published in final edited form as: Org Lett. 2009 Jun 4;11(11):2285–2288. doi: 10.1021/ol900590t

Table 2.

Scope of the Mn(III)-mediated cycloaddition

entry substrate Products % yield
1 graphic file with name nihms121381t2.jpg graphic file with name nihms121381t3.jpg 82 Z/E > 10:1
2 graphic file with name nihms121381t4.jpg graphic file with name nihms121381t5.jpg 70
3a graphic file with name nihms121381t6.jpg graphic file with name nihms121381t7.jpg 76
4b graphic file with name nihms121381t8.jpg graphic file with name nihms121381t9.jpg 72
5 graphic file with name nihms121381t10.jpg graphic file with name nihms121381t11.jpg 26 (23) 27 (60)
6 graphic file with name nihms121381t12.jpg graphic file with name nihms121381t13.jpg 69
7 graphic file with name nihms121381t14.jpg graphic file with name nihms121381t15.jpg 74

Reaction conditions: Mn(OAc)3·2H2O (2.1 equiv), Cu(OAc)2·H2O (1.0 equiv), AcOH, rt, 4 h.

a

Reaction performed at 65 °C for 15 min.

b

Reaction performed at 35 °C for 4 h.

c

dr = 4:1 (major diastereomer shown).