. Author manuscript; available in PMC: 2010 Aug 1.

Published in final edited form as: Eur J Pharmacol. 2009 May 23;615(1-3):102–107. doi: 10.1016/j.ejphar.2009.05.010

Table 1. 1-Pentyl-3-phenylacetylindoles: Relationship between cannabinoid CB₁ receptor affinity and potency for producing THC-like discriminative stimulus effects.


Compound		Molecular weight	CB₁ Affinity K_i(nM) ± S.E.M.	ED₅₀(95% CL) μmol/kg
Δ⁹-THC	Group 1	314	41 ± 2 ^a	12 (6-24)
Δ⁹-THC	Group 2			11 (7-18)
JWH-202
1-pentyl-3-(4-methoxyphenylacetyl)indole		350	1678 ± 62 ^b	No substitution
JWH-204
1-pentyl-3-(2-chlorophenylacetyl)indole		353	13 ± 1 ^b	8 (2-28)
JWH-205
1-pentyl-3-phenylacetylindole		319	134 ± 23 ^b	92 (23-ucl out of range)

Table 1. 1-Pentyl-3-phenylacetylindoles: Relationship between cannabinoid CB1 receptor affinity and potency for producing THC-like discriminative stimulus effects.