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. Author manuscript; available in PMC: 2010 Jan 30.
Published in final edited form as: J Neurosci Methods. 2008 Sep 19;176(2):172–181. doi: 10.1016/j.jneumeth.2008.09.013

Figure 7.

Figure 7

Relative mRNA expression of NMDA receptor subunits and PV in PV-ir interneurons in normal adult rat PFC versus treatment with MK-801. A, it is clear that the mRNA expression of NR2A subunit is significantly higher than that of NR2B (p<0.05) in the PV-ir interneurons of adult rat PFC (postnatal day 90). Note the high expression of PV and undetectable level of NR2D subunit in PV-ir cells. B, subchronic treatment with MK-801 significantly downregulated the mRNA expression of PV to an almost undetectable level (337.2-fold) and all subunits of NMDA receptors in PV-ir interneurons, i.e., 6.13-fold for NR1, 17.7-fold for NR2A, and 21.0-fold for NR2B (p<0.05).