FIGURE 6.

Three-dimensional structure of the complexes formed between Hma and AdoHcy, sinefungin, and SADAE. A, ribbon representation of Hma (coordinates from the Hma-AdoHcy complex) showing helices and β-strands of the conserved AdoMet-MTs core in cyan and red, respectively. Helices of the MA-MT embellishment pattern are shown in green. The three ligands were superimposed and are shown as sticks with carbon atoms of the adenosine core in yellow and nitrogen, oxygen, and sulfur atoms in blue, red, and green, respectively. The carbon atoms of the decylaminoethyl group of SADAE are shown in navy. B, perpendicular view. The van der Waals surfaces of SADAE atoms are also depicted with dots.