FIGURE 7.

Binding of AdoHcy, sinefungin, and SADAE to Hma. Stereo image of the chemical environment of AdoHcy (A), sinefungin (B), and SADAE (C). The three ligands and the residues defining the corresponding binding sites in Hma are shown and labeled. Nitrogen, oxygen, and sulfur atoms are shown in blue, red, and green, respectively. Carbon atoms are shown in light blue for the protein and yellow for AdoHcy, sinefungin, and SADAE. The van der Waals surfaces of interacting atoms (listed in supplemental Table 1) are also shown. Water molecules are shown as red spheres. Hydrogen bonds are represented by black dotted lines.